A wrong-way chain reaction crash on a Staten Island highway left one woman dead and four others hospitalized early Saturday, cops said.

The 66-year-old victim was driving a Kia Seltos headed south on the West Shore Expressway near exit 8 in Travis when she collided with a 36-year-old woman driving a Range Rover heading north in the southbound lane about 5:35 a.m., cops said.

A 21-year-old woman heading south in the same lane then collided with both cars.

Medics pronounced the Kia driver dead at the scene.

The Range Rover driver, the Jeep driver, and a 21-year-old woman and a 22-year-old man riding in the Jeep were taken to Richmond University Medical Center, where they are expected to survive.

An investigation was underway by members of the NYPD’s Collision Investigation Squad. No arrests have been made.

The fatal crash occurred about 15 hours after two women were killed and four people were hospitalized in the Bronx as an 81-year-old driver in a white Mercedes slammed into multiple pedestrians, cops said.

Cops said the driver, traveling west on Allerton Ave., was unable to stop his Mercedes sedan and went barreling into the intersection at Holland Ave. around 2:14 p.m., striking four pedestrians and four cars.

“He waited for about five minutes, and then he sped up. I heard him change gears about twice,” witness Mojalli Al-Abdi, 40, who owns the nearby Allerton Halal Meat Market, told the Daily News. “There were three people that flew in the air. He ran into people and crashed into all of the cars.”

The four pedestrians were rushed to Jacobi Medical Center, where two of the women, ages 57 and 39, died, police said. An 84-year-old woman was listed in critical condition, while another woman, 60, struck in the crash is expected to survive.

There were no immediate arrests.